For Hilliard Bradley’s Norris family, basketball is in their DNA

Photo provided by Brett Norris COLUMBUS, Ohio – Being part of a basketball family isn’t always filled with what Hilliard Bradley men’s basketball coach Brett Norris calls ‘sunshine and rainbows.’ One memory he will always cherish was March 8, 2022, when he along with his wife, Carrie Norris, and three of their children traveled to …

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Evaluation of automated techniques for extraction of circulating cell-free DNA for implementation in standardized high-throughput workflows

Huebner, H. et al. Filtration based assessment of CTCs and Cell Search® based assessment are both powerful predictors of prognosis for metastatic breast cancer patients. BMC Cancer 18, 204. https://doi.org/10.1186/s12885-018-4115-1 (2018). Article  Google Scholar  Banys-Paluchowski, M., Krawczyk, N. & Fehm, T. Liquid biopsy in breast cancer. Geburtshilfe Frauenheilkd 80, 1093–1104. https://doi.org/10.1055/a-1124-7225 (2020). Article  Google Scholar  …

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Sampling environmental DNA from trees and soil to detect cryptic arboreal mammals

Fully terrestrial eDNA sampling approaches offer a potentially powerful addition to biodiversity monitoring efforts23,24. However, protocols for using eDNA-based methods to characterize terrestrial biodiversity, and vertebrate communities in particular, are still nascent27,28,30. In this study, we show for the first time that an eDNA metabarcoding approach can be used to broadly characterize tree-dwelling mammal communities …

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Synthetic genetic circuit to refine CAR T therapy

airplane cabin control panel getty Here we describe a new way to control CAR T therapy through synthetic gene circuits. For more information on monitoring CAR T therapy, read our article on the Using Antibody Switches to Control CAR T Cell Activation. Previous installments also discuss the Fundamentals of CAR-T and its applications for B …

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Ahead of the curve: New techniques advance DNA nanotech

December 27, 2022 DNA nanotechnology is a rapidly evolving field, thriving on the borders between biology and chemistry. Pioneering design principles allow researchers to build an extraordinary variety of two- and three-dimensional shapes on a scale of just billionths of a meter, using the molecule of life as a building material. In a new study, …

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Efficient modification and preparation of circular DNA for expression in cell culture

Conceptual introduction With this method, which consists of a single tube two-step reaction followed by a typical spin column-based DNA cleanup, a researcher can produce a batch of Circular Vectors in 3 h. The Circular Vector method simplifies making small variable targeting components that work in conjunction with an invariable large plasmid coding for Cas9 and/or …

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New method uses artificial DNA to target and kill cancer cells

Researchers at the University of Tokyo have used artificial DNA to attack and kill cancer cells in a whole new way. The method was effective in laboratory tests against cells derived from human cervical cancer and breast cancer, and against malignant melanoma cells from mice. The team created a chemically synthesized, hairpin-shaped pair of anticancer …

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